Abstract
The human SIRT1 is a nuclear enzyme from the class III histone deacetylases (HDACs) which is widely distributed in mammalian tissues. A variety of SIRT1 substrates hints that this protein is involved in the regulation of diverse biological processes, including cell survival, apoptosis, gluconeogenesis, adipogenesis, lipolysis, stress resistance, muscle differentiation, and insulin secretion. This review emphasizes catalytic properties of SIRT1 and its role in apoptosis, insulin pathway, and neuron survival.
Keywords: FOXO factors, NAD+-dependent deacetylase, p53, resveratrol, Sir2, SIRT1
Mini-Reviews in Medicinal Chemistry
Title: Physiological and Pathophysiological Functions of SIRT1
Volume: 9 Issue: 3
Author(s): M. Wojcik, K. Mac-Marcjanek and L. A. Wozniak
Affiliation:
Keywords: FOXO factors, NAD+-dependent deacetylase, p53, resveratrol, Sir2, SIRT1
Abstract: The human SIRT1 is a nuclear enzyme from the class III histone deacetylases (HDACs) which is widely distributed in mammalian tissues. A variety of SIRT1 substrates hints that this protein is involved in the regulation of diverse biological processes, including cell survival, apoptosis, gluconeogenesis, adipogenesis, lipolysis, stress resistance, muscle differentiation, and insulin secretion. This review emphasizes catalytic properties of SIRT1 and its role in apoptosis, insulin pathway, and neuron survival.
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Cite this article as:
Wojcik M., Mac-Marcjanek K. and Wozniak A. L., Physiological and Pathophysiological Functions of SIRT1, Mini-Reviews in Medicinal Chemistry 2009; 9 (3) . https://dx.doi.org/10.2174/1389557510909030386
DOI https://dx.doi.org/10.2174/1389557510909030386 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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