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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Physiological and Pathophysiological Functions of SIRT1

Author(s): M. Wojcik, K. Mac-Marcjanek and L. A. Wozniak

Volume 9, Issue 3, 2009

Page: [386 - 394] Pages: 9

DOI: 10.2174/1389557510909030386

Price: $65

Abstract

The human SIRT1 is a nuclear enzyme from the class III histone deacetylases (HDACs) which is widely distributed in mammalian tissues. A variety of SIRT1 substrates hints that this protein is involved in the regulation of diverse biological processes, including cell survival, apoptosis, gluconeogenesis, adipogenesis, lipolysis, stress resistance, muscle differentiation, and insulin secretion. This review emphasizes catalytic properties of SIRT1 and its role in apoptosis, insulin pathway, and neuron survival.

Keywords: FOXO factors, NAD+-dependent deacetylase, p53, resveratrol, Sir2, SIRT1


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