Natural Product Inhibitors of Hsp90: Potential Leads for Drug Discovery

M.   W.   Amolins; B.   S.J.   Blagg

doi:10.2174/138955709787316056

Abstract

Heat shock protein 90 has emerged as a promising target for the treatment of cancer and neurodegenerative diseases. This review summarizes recent advancements towards the development of natural products as they pertain to the biological and chemical understanding of this molecular chaperone.

Keywords: Hsp90, inhibitors, cancer, neurodegenerative diseases, natural products