Identification of GCP II Inhibitors Based on 4-Arylmethyl-3-(4- carboxyphenyl)-5-hydroxyisoxazole Scaffold

Title: Identification of GCP II Inhibitors Based on 4-Arylmethyl-3-(4- carboxyphenyl)-5-hydroxyisoxazole Scaffold

Volume: 6 Issue: 1

Author(s): M. Teus, A. Jirgensons, M. Dambrova, R. Mezhapuke, C. G. Parsons and W. Danysz

Affiliation:

Keywords: Glutamate carboxypeptidase II, Glutamate, 5-hydroxyisoxazole, Lipophilicity, Synthesis

Abstract: Screening of a non-ionizable compound library and hit optimization studies has resulted in a series of compounds based on a 4-arylmethyl-3-(4-carboxyphenyl)-5-hydroxyisoxazole scaffold with GCP II inhibitory activity in the low micromolar range.

Cite this article as:

Teus M., Jirgensons A., Dambrova M., Mezhapuke R., Parsons G. C. and Danysz W., Identification of GCP II Inhibitors Based on 4-Arylmethyl-3-(4- carboxyphenyl)-5-hydroxyisoxazole Scaffold, Letters in Drug Design & Discovery 2009; 6 (1) . https://dx.doi.org/10.2174/157018009787158544