Copper Catalyzed Coupling of α-Bromocarboxylate with ω-Lactam

Katerina      Brychtova; Oldrich      Farsa; Jozef      Csollei

doi:10.2174/157017809787003205

Abstract

This paper especially deals with the problem associated with the reaction of α-bromocarboxyl compound and 5- membered ω-lactam ring. Specific heterogeneous copper catalyst was used to achieve the C – N nucleophilic coupling. Synthetic pathway of ethyl-6-(2,5-dioxopyrrolidin-1-yl)-2-(2-oxopyrrolidin-1-yl)hexanoate as the key intermediate of new potential transdermal enhancers is described. All generated compounds were characterized by NMR and IR spectroscopy.

Keywords: Copper catalyst, C, –, N coupling, ω-lactam derivatives, penetration enhancers

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Letters in Organic Chemistry

Title: Copper Catalyzed Coupling of α-Bromocarboxylate with ω-Lactam

Volume: 6 Issue: 1

Author(s): Katerina Brychtova, Oldrich Farsa and Jozef Csollei

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Keywords: Copper catalyst, C, –, N coupling, ω-lactam derivatives, penetration enhancers

Abstract: This paper especially deals with the problem associated with the reaction of α-bromocarboxyl compound and 5- membered ω-lactam ring. Specific heterogeneous copper catalyst was used to achieve the C – N nucleophilic coupling. Synthetic pathway of ethyl-6-(2,5-dioxopyrrolidin-1-yl)-2-(2-oxopyrrolidin-1-yl)hexanoate as the key intermediate of new potential transdermal enhancers is described. All generated compounds were characterized by NMR and IR spectroscopy.

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Brychtova Katerina, Farsa Oldrich and Csollei Jozef, Copper Catalyzed Coupling of α-Bromocarboxylate with ω-Lactam, Letters in Organic Chemistry 2009; 6 (1) . https://dx.doi.org/10.2174/157017809787003205