Facile Regioselective Green Synthesis of Triazolo [4,3-a] Pyrimidines in Aqueous Medium

Title: Facile Regioselective Green Synthesis of Triazolo [4,3-a] Pyrimidines in Aqueous Medium

Volume: 6 Issue: 1

Author(s): Anshu Dandia, Ruby Singh, Dharmendra Singh and Kapil Arya

Affiliation:

Keywords: α-Cyano acrylates, microwave irradiations, ultrasound, aqueous medium, triazolopyrimidines

Abstract: Regioselectivity is investigated in multi-component reaction of amino triazole, carbonyl compounds and α- cyano esters derivative and exclusive synthesis of triazolopyrimidines is developed in aqueous medium in excellent yields in shorter period using microwaves or ultrasonic waves. Path and mechanism of the reaction has also been discussed. The operational simplicity, environmental friendly conditions, regioselective formation of target product, high yield in significantly very short reaction time, are major benefits.

Cite this article as:

Dandia Anshu, Singh Ruby, Singh Dharmendra and Arya Kapil, Facile Regioselective Green Synthesis of Triazolo [4,3-a] Pyrimidines in Aqueous Medium, Letters in Organic Chemistry 2009; 6 (1) . https://dx.doi.org/10.2174/157017809787003124