Abstract
Toll like receptors (TLR) play a critical role in the recognition and response of pathogens by the innate immune system. Pathogen engagement of the TLR-MyD88 pathway favours the development of a protective Th1-biased T cell response. Interruption of TLR recognition or signalling has profound effects on innate immunity. Agonists or antagonists of specific TLRs modulate the host response to microbial infections and have effects beyond infectious control and may be used as immunostimulators in vaccine, cancer, inflammatory disorders and allergy.
Keywords: TLR, IL1R, infection, vaccine, inflammation, immunomodulation
Infectious Disorders - Drug Targets
Title: Toll Like Receptor - Potential Drug Targets in Infectious Disease
Volume: 8 Issue: 4
Author(s): Francois Erard and Bernhard Ryffel
Affiliation:
Keywords: TLR, IL1R, infection, vaccine, inflammation, immunomodulation
Abstract: Toll like receptors (TLR) play a critical role in the recognition and response of pathogens by the innate immune system. Pathogen engagement of the TLR-MyD88 pathway favours the development of a protective Th1-biased T cell response. Interruption of TLR recognition or signalling has profound effects on innate immunity. Agonists or antagonists of specific TLRs modulate the host response to microbial infections and have effects beyond infectious control and may be used as immunostimulators in vaccine, cancer, inflammatory disorders and allergy.
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Cite this article as:
Erard Francois and Ryffel Bernhard, Toll Like Receptor - Potential Drug Targets in Infectious Disease, Infectious Disorders - Drug Targets 2008; 8 (4) . https://dx.doi.org/10.2174/187152608786734179
DOI https://dx.doi.org/10.2174/187152608786734179 |
Print ISSN 1871-5265 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3989 |
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