Abstract
Inhibitors of dipeptidyl peptidase IV (DPP-4) have emerged as an important new class of therapeutic agents for type two diabetes. Various medicinal chemistry approaches have been applied to this area and have resulted in the identification of numerous late-stage development compounds. The discoveries of several of the most advanced DPP-4 inhibitors are reviewed.
Keywords: Dipeptidyl Peptidase IV (DPP-4), Glucagon-like Peptide-1 (GLP-1), vildagliptin (Galvus®), saxagliptin (Onglyza™), sitagliptin (Januvia™), linagliptin (Ondero®), alogliptin
Current Topics in Medicinal Chemistry
Title: Medicinal Chemistry Approaches to the Inhibition of Dipeptidyl Peptidase IV
Volume: 8 Issue: 17
Author(s): Stephen L. Gwaltney II
Affiliation:
Keywords: Dipeptidyl Peptidase IV (DPP-4), Glucagon-like Peptide-1 (GLP-1), vildagliptin (Galvus®), saxagliptin (Onglyza™), sitagliptin (Januvia™), linagliptin (Ondero®), alogliptin
Abstract: Inhibitors of dipeptidyl peptidase IV (DPP-4) have emerged as an important new class of therapeutic agents for type two diabetes. Various medicinal chemistry approaches have been applied to this area and have resulted in the identification of numerous late-stage development compounds. The discoveries of several of the most advanced DPP-4 inhibitors are reviewed.
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Cite this article as:
Gwaltney II L. Stephen, Medicinal Chemistry Approaches to the Inhibition of Dipeptidyl Peptidase IV, Current Topics in Medicinal Chemistry 2008; 8 (17) . https://dx.doi.org/10.2174/156802608786413519
DOI https://dx.doi.org/10.2174/156802608786413519 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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