Thermal N-9 → N-7 Isomerization of (6-Substituted)-9-(2,3-Dihydro-5H-1,4-Benzodioxepin-3-yl)-9H-Purines in Solution: Mechanistic Aspects

Title: Thermal N-9 → N-7 Isomerization of (6-Substituted)-9-(2,3-Dihydro-5H-1,4-Benzodioxepin-3-yl)-9H-Purines in Solution: Mechanistic Aspects

Volume: 5 Issue: 2

Author(s): M. A. Gallo, A. Espinosa and J. M. Campos

Affiliation:

Keywords: Amination, antitumour compounds, benzodioxepins, purines, suzuki reaction, trifluoromethylation reaction

Abstract: The purine ring system is undoubtedly among the most ubiquitous of all the heterocyclic compounds. In recent years modified purine structures both of natural and synthetic origin have been a rich source of biologically active materials. The halogen at 6 position of the purine moiety of the (RS)-9 or 7-(2,3-dihydro-5H-1,4-benzodioxepin-3-yl)-9H-or 7Hpurines shows an interesting reactivity which is presented and discussed. The anticarcinogenic potential of the target molecules is reported against the MCF-7 cancer cell line.

Cite this article as:

Gallo A. M., Espinosa A. and Campos M. J., Thermal N-9 → N-7 Isomerization of (6-Substituted)-9-(2,3-Dihydro-5H-1,4-Benzodioxepin-3-yl)-9H-Purines in Solution: Mechanistic Aspects, Mini-Reviews in Organic Chemistry 2008; 5 (2) . https://dx.doi.org/10.2174/157019308784223569