Abstract
The metal-catalyzed cross-coupling reaction of oxazoles is discussed in this review. Initially, preparation of metallated oxazoles (oxazole-M) and halo- and trifloyloxazoles (oxazole-X) is outlined. After that, comprehensive examples of Negishi, Stille, Suzuki-Miyaura, and Sonogashira reactions at each three position in oxazoles (C-2, C-4, and C-5) are detailed with showing both types of reactions [route A (reaction of oxazol-M and Ar-X) and route B (reaction of oxazole- X and Ar-M)].
Keywords: Oxazoles, cross-coupling, Negishi reaction, Stille reaction, Suzuki-Miyaura reaction, Sonogashira reaction
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