Abstract
Mucus hypersecretion is common in inflammatory and allergic lung disease. Excessive mucus production leads to obstruction of airways and favours bacterial colonization. Advances in understanding the signalling and transduction pathways of mucin gene expression as well as mechanisms of mucin protein production and secretion have defined new therapeutic targets. Conventional therapies include anticholinergics, β2-adrenoceptor agonists, glucocorticosteroids, mucolytics and macrolide antibiotics. Novel therapeutic approaches are inhibitors of cholinergic nerve activity, tachykinin receptor antagonists, epoxygenase inducers, inhibitors of mucin exocytosis, inhibitors of mucin synthesis and goblet cell hyperplasia, inducers of goblet cell apoptosis and P2Y2 purinoceptor antagonists to inhibit mucin secretion. After providing a short overview on conventional therapies this review will focus on new therapeutic targets.
Keywords: Airway, allergy, inflammation, mucus, treatment
Inflammation & Allergy - Drug Targets (Discontinued)
Title: Emerging Mucus Regulating Drugs in Inflammatory and Allergic Lung Disease
Volume: 7 Issue: 1
Author(s): Hans-Peter Hauber and Peter Zabel
Affiliation:
Keywords: Airway, allergy, inflammation, mucus, treatment
Abstract: Mucus hypersecretion is common in inflammatory and allergic lung disease. Excessive mucus production leads to obstruction of airways and favours bacterial colonization. Advances in understanding the signalling and transduction pathways of mucin gene expression as well as mechanisms of mucin protein production and secretion have defined new therapeutic targets. Conventional therapies include anticholinergics, β2-adrenoceptor agonists, glucocorticosteroids, mucolytics and macrolide antibiotics. Novel therapeutic approaches are inhibitors of cholinergic nerve activity, tachykinin receptor antagonists, epoxygenase inducers, inhibitors of mucin exocytosis, inhibitors of mucin synthesis and goblet cell hyperplasia, inducers of goblet cell apoptosis and P2Y2 purinoceptor antagonists to inhibit mucin secretion. After providing a short overview on conventional therapies this review will focus on new therapeutic targets.
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Cite this article as:
Hauber Hans-Peter and Zabel Peter, Emerging Mucus Regulating Drugs in Inflammatory and Allergic Lung Disease, Inflammation & Allergy - Drug Targets (Discontinued) 2008; 7 (1) . https://dx.doi.org/10.2174/187152808784165153
DOI https://dx.doi.org/10.2174/187152808784165153 |
Print ISSN 1871-5281 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-4055 |
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