Abstract
In recent years it has become apparent that the liver holds a distinct immunological position. Previously described as a “graveyard” for T cells activated in the periphery, emerging evidence indicates that this organ may have a more active role in mediating tolerance. Attenuated immune responses in the liver can be beneficial in the transplantation setting, as liver transplants are more readily accepted than other organ allografts even in the absence of immunosuppressive drugs. However, the ability of the liver to induce immunological unresponsiveness could be exploited by some pathogens, such as the hepatitis C virus (HCV), to establish chronic infections with potentially fatal outcomes. Understanding the mechanisms controlling the balance between intrahepatic tolerance and immunity is critical in order to design new strategies to enhance acceptance of solid organ allografts and to promote efficient immune responses against HCV. In this article, we will review current knowledge of the mechanisms regulating intrahepatic immunity and discuss how these mechanisms might potentially be targeted to achieve advantageous clinical outcomes in transplantation and persistent hepatotropic infections.
Keywords: Liver, tolerance, T cells, hepatitis C virus, transplantation
Inflammation & Allergy - Drug Targets (Discontinued)
Title: Liver Tolerance and the Manipulation of Immune Outcomes
Volume: 7 Issue: 1
Author(s): Lauren E. Holz, Geoffrey W. McCaughan, Volker Benseler, Patrick Bertolino and David G. Bowen
Affiliation:
Keywords: Liver, tolerance, T cells, hepatitis C virus, transplantation
Abstract: In recent years it has become apparent that the liver holds a distinct immunological position. Previously described as a “graveyard” for T cells activated in the periphery, emerging evidence indicates that this organ may have a more active role in mediating tolerance. Attenuated immune responses in the liver can be beneficial in the transplantation setting, as liver transplants are more readily accepted than other organ allografts even in the absence of immunosuppressive drugs. However, the ability of the liver to induce immunological unresponsiveness could be exploited by some pathogens, such as the hepatitis C virus (HCV), to establish chronic infections with potentially fatal outcomes. Understanding the mechanisms controlling the balance between intrahepatic tolerance and immunity is critical in order to design new strategies to enhance acceptance of solid organ allografts and to promote efficient immune responses against HCV. In this article, we will review current knowledge of the mechanisms regulating intrahepatic immunity and discuss how these mechanisms might potentially be targeted to achieve advantageous clinical outcomes in transplantation and persistent hepatotropic infections.
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Cite this article as:
Holz E. Lauren, McCaughan W. Geoffrey, Benseler Volker, Bertolino Patrick and Bowen G. David, Liver Tolerance and the Manipulation of Immune Outcomes, Inflammation & Allergy - Drug Targets (Discontinued) 2008; 7 (1) . https://dx.doi.org/10.2174/187152808784165225
DOI https://dx.doi.org/10.2174/187152808784165225 |
Print ISSN 1871-5281 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-4055 |
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