Abstract
Mycophenolate mofetil, an inosine monophosphate dehydrogenase inhibitor, that inhibits the de novo pathway of guanosine nucleotide synthesis, inhibits proliferative responses of T and B lymphocytes as well as antibody production by B-lymphocytes. It is indicated for the prophylaxis of organ rejection after allogeneic cardiac, hepatic and renal transplants. It has also been recently used with good success in patients with lupus nephritis. Based on these actions mycophenolate mofetil appears to be a novel agent in the treatment of systemic sclerosis.
Keywords: Mycophenolate mofetil, Mycophenolic acid, Fibsosis, Systemic sclerosis, Scleroderma, Treatment
Letters in Drug Design & Discovery
Title: Mycophenolate Mofetil for the Treatment of Systemic Sclerosis
Volume: 5 Issue: 2
Author(s): Manisha Naik, Max Shenin and Chris T. Derk
Affiliation:
Keywords: Mycophenolate mofetil, Mycophenolic acid, Fibsosis, Systemic sclerosis, Scleroderma, Treatment
Abstract: Mycophenolate mofetil, an inosine monophosphate dehydrogenase inhibitor, that inhibits the de novo pathway of guanosine nucleotide synthesis, inhibits proliferative responses of T and B lymphocytes as well as antibody production by B-lymphocytes. It is indicated for the prophylaxis of organ rejection after allogeneic cardiac, hepatic and renal transplants. It has also been recently used with good success in patients with lupus nephritis. Based on these actions mycophenolate mofetil appears to be a novel agent in the treatment of systemic sclerosis.
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Cite this article as:
Naik Manisha, Shenin Max and Derk T. Chris, Mycophenolate Mofetil for the Treatment of Systemic Sclerosis, Letters in Drug Design & Discovery 2008; 5 (2) . https://dx.doi.org/10.2174/157018008783928454
DOI https://dx.doi.org/10.2174/157018008783928454 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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