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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Phosphomolybdic Acid Supported on Silica Gel as Mild, Efficient and Cost-Effective Catalyst for Chemoselective Protection of Amines with di-tert-Butyl Dicarbonate

Author(s): J. S. Yadav, Y. Gopala Rao, A. Ramesh Reddy, A. V. Narsaiah and B. V. Subba Reddy

Volume 5, Issue 2, 2008

Page: [116 - 119] Pages: 4

DOI: 10.2174/157017808783743957

Price: $65

Abstract

A variety of amines were protected as their N-Boc derivatives using phosphomolybdic acid supported on silica gel as a heterogeneous catalyst. The catalyst is more effective and highly selective for the protection of amines under mild conditions and it can be recovered and reused in subsequent reactions without apparent loss of activity.

Keywords: Amines, Boc-anhydride, PMA-SiO2, protection, solid acids


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