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Current Rheumatology Reviews

Editor-in-Chief

ISSN (Print): 1573-3971
ISSN (Online): 1875-6360

T-Cell Dysregulation in Systemic Lupus Erythematosus: Pathophysiology and Opportunities for Biomarker Development

Author(s): Frances C. Hall, Christine Bryson and Robert Busch

Volume 4, Issue 1, 2008

Page: [23 - 33] Pages: 11

DOI: 10.2174/157339708783497892

Price: $65

Abstract

T cells in SLE patients are dysfunctional as a result of altered signalling inputs and altered signal processing. They contribute to pathogenesis through expansion of autoreactive T cells, aberrant B-cell help and direct T cell-mediated tissue damage. Tissue inflammation and damage, in turn, produce nuclear autoantigens and perpetuate antigen presentation to T cells. Improvements in T cell-targeted therapy will require biomarkers of T-cell dysfunction that predict clinical response. Criteria for defining such biomarkers in SLE are discussed here. Phenotypes associated with T-cell activation, specific effector functions, and/or altered proliferative and homeostatic dynamics are promising candidates.

Keywords: Biomarker, T-cell activation, T-cell signalling, systemic lupus erythematosus, autoimmunity, immunodeficiency, proliferation, lymphopenia, effector function


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