Synthesis, Molecular Docking and PTP1B Inhibitory Activity of Functionalized 4,5-Dihydronaphthofurans and Dibenzofurans

Atul      Goel; Manish      Dixit; Uzma      Saeed; Amit      Kumar; Mohammad   Imran   Siddiqi; Akhilesh   K.   Tamrakar; Arvind   K.   Srivastava

doi:10.2174/157340608783331515

Abstract

Protein tyrosine phosphatase 1B (PTP1B) is an enzyme that plays a critical role in down-regulating insulin signaling through dephosphorylation of the insulin receptor. Inhibitors of PTP1B showed increased insulin sensitivity and normalize plasma glucose level and thus are useful therapeutic agents for the treatment of diabetes. A series of functionalized 4,5-dihydronaphthofurans and dibenzofurans were synthesized, studied through molecular docking and evaluated for their PTP1B inhibitory activity.

Keywords: Diabetes, PTP1B inhibitor, 4,5-dihydronaphthofuran, dibenzofuran, molecular docking

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