Abstract
The murine carotid artery ligation (CAL) model has been widely used in the research of intimal hyperplasia, a major pathological process in vascular diseases, such as atherosclerosis and restenosis after angioplasty. Using a variety of gene knockout or transgenic mice and different pharmacological interventions, these studies have yielded significant new findings that contribute not only to unraveling the basic molecular mechanisms involved in the pathogenesis of intimal hyperplasia, but also to the identification of novel targets for intervention of these diseases. The current review outlines the findings derived from the murine CAL model, including studies run by the authors, covering the impacts of hyperlipidemia, pro-inflammatory factors, endothelial dysfunction, protease activity and growth mediators on neointimal hyperplasia.
Keywords: Intimal hyperplasia, carotid artery ligation, hyperlipidemia, endothelial dysfunction, protease, angiotensin II
Current Vascular Pharmacology
Title: Mechanisms of Intimal Hyperplasia Learned from a Murine Carotid Artery Ligation Model
Volume: 6 Issue: 1
Author(s): Le-Ning Zhang, John F. Parkinson, Christopher Haskell and Yi-Xin Wang
Affiliation:
Keywords: Intimal hyperplasia, carotid artery ligation, hyperlipidemia, endothelial dysfunction, protease, angiotensin II
Abstract: The murine carotid artery ligation (CAL) model has been widely used in the research of intimal hyperplasia, a major pathological process in vascular diseases, such as atherosclerosis and restenosis after angioplasty. Using a variety of gene knockout or transgenic mice and different pharmacological interventions, these studies have yielded significant new findings that contribute not only to unraveling the basic molecular mechanisms involved in the pathogenesis of intimal hyperplasia, but also to the identification of novel targets for intervention of these diseases. The current review outlines the findings derived from the murine CAL model, including studies run by the authors, covering the impacts of hyperlipidemia, pro-inflammatory factors, endothelial dysfunction, protease activity and growth mediators on neointimal hyperplasia.
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Cite this article as:
Zhang Le-Ning, Parkinson F. John, Haskell Christopher and Wang Yi-Xin, Mechanisms of Intimal Hyperplasia Learned from a Murine Carotid Artery Ligation Model, Current Vascular Pharmacology 2008; 6 (1) . https://dx.doi.org/10.2174/157016108783331321
DOI https://dx.doi.org/10.2174/157016108783331321 |
Print ISSN 1570-1611 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6212 |
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Cardiovascular disease still remains the leading cause of death in Chronic and End Stage Kidney Disease, accounting for more than half of all deaths in dialysis patients. During the past decade, research has been focused on novel therapeutic agents that might delay or even reverse cardiovascular disease and vascular calcification, ...read more
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