One-Pot Synthesis of Norfloxacin Ethyl Ester from 3-Chloro-4- Fluoroaniline in Ionic Liquid

Shengdong      Zhu; Yuanxin      Wu; Ziniu      Yu; Xizhou      Shen; Chengmiao      Xu; Jun      Yao; Hong      Huang; Shiwei      Jin

doi:10.2174/157017808783330126

Abstract

Norfloxacin ethyl ester was prepared from 3-chloro-4-fluoroaniline in ionic liquid in a one-pot procedure by condensation with EMME [ethoxymethylenemalonic diethyl ester], cyclization, ethylation and condensation with anhydrous piperazine. After its hydrolysis, norfloxacin was obtained with an overall yield of 72.7%.

Keywords: Synthesis, norfloxacin ethyl ester, ionic liquid

Rights & Permissions Print Cite

Letters in Organic Chemistry

Title: One-Pot Synthesis of Norfloxacin Ethyl Ester from 3-Chloro-4- Fluoroaniline in Ionic Liquid

Volume: 5 Issue: 1

Author(s): Shengdong Zhu, Yuanxin Wu, Ziniu Yu, Xizhou Shen, Chengmiao Xu, Jun Yao, Hong Huang and Shiwei Jin

Affiliation:

Keywords: Synthesis, norfloxacin ethyl ester, ionic liquid

Abstract: Norfloxacin ethyl ester was prepared from 3-chloro-4-fluoroaniline in ionic liquid in a one-pot procedure by condensation with EMME [ethoxymethylenemalonic diethyl ester], cyclization, ethylation and condensation with anhydrous piperazine. After its hydrolysis, norfloxacin was obtained with an overall yield of 72.7%.

Export Options

Export File:

RIS (for EndNote, Reference Manager, ProCite)

BibTeX

Text

Content:

Citation Only

Citation and Abstract

About this article

Cite this article as:

Zhu Shengdong, Wu Yuanxin, Yu Ziniu, Shen Xizhou, Xu Chengmiao, Yao Jun, Huang Hong and Jin Shiwei, One-Pot Synthesis of Norfloxacin Ethyl Ester from 3-Chloro-4- Fluoroaniline in Ionic Liquid, Letters in Organic Chemistry 2008; 5 (1) . https://dx.doi.org/10.2174/157017808783330126