Abstract
Current asthma therapy is aimed at controlling disease symptoms. A subset of asthma patients remains symptomatic despite optimal therapy indicating that an unmet medical need exists for these patients. Innovative therapeutics are needed to treat the unmet need in asthma and biopharmaceutical approaches may provide an opportunity for identifying these agents. It is proposed that airway remodeling contributes to asthma symptoms and this feature of disease pathology may be a target for future therapies. The current review focuses on the contribution of one feature of airway remodeling, subepithelial fibrosis, towards disease and highlights some of the mechanisms that may contribute to this feature of airway remodeling. Further, some potential molecular targets are identified for consideration for therapeutic intervention.
Keywords: Biopharmaceuticals, asthma, remodeling, unmet need
Current Pharmaceutical Design
Title: Biopharmaceutical Therapeutics for Asthma Remodeling
Volume: 12 Issue: 25
Author(s): A. M. Das, D. E. Griswold, T. J. Torphy and L. Li
Affiliation:
Keywords: Biopharmaceuticals, asthma, remodeling, unmet need
Abstract: Current asthma therapy is aimed at controlling disease symptoms. A subset of asthma patients remains symptomatic despite optimal therapy indicating that an unmet medical need exists for these patients. Innovative therapeutics are needed to treat the unmet need in asthma and biopharmaceutical approaches may provide an opportunity for identifying these agents. It is proposed that airway remodeling contributes to asthma symptoms and this feature of disease pathology may be a target for future therapies. The current review focuses on the contribution of one feature of airway remodeling, subepithelial fibrosis, towards disease and highlights some of the mechanisms that may contribute to this feature of airway remodeling. Further, some potential molecular targets are identified for consideration for therapeutic intervention.
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Cite this article as:
Das M. A., Griswold E. D., Torphy J. T. and Li L., Biopharmaceutical Therapeutics for Asthma Remodeling, Current Pharmaceutical Design 2006; 12 (25) . https://dx.doi.org/10.2174/138161206778194097
DOI https://dx.doi.org/10.2174/138161206778194097 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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