synthesis and Structure-Activity Relationships of 2,3-Benzodiazepines as AMPA Receptor Antagonists

Title: synthesis and Structure-Activity Relationships of 2,3-Benzodiazepines as AMPA Receptor Antagonists

Volume: 1 Issue: 3

Author(s): M. Zappala, S. Grasso, N. Micale, S. Polimeni and C. De Micheli

Affiliation:

Keywords: 2,3-Benzodiazepines, AMPA Receptor, glutamate receptor antagonists, neurodegenerative disorders, Stroke, Epilepsy, Anticonvulsant, Neuroprotective

Abstract: There is increasing evidence of the potential therapeutic utility of glutamate receptor antagonists in the treatment of several neurodegenerative disorders, including stroke and epilepsy. In the last few years noncompetitive AMPA receptor antagonists have received considerable attention due to their therapeutic potentiality. The discovery of GYKI 52466, the prototype of noncompetitive AMPA receptor antagonists endowed with anticonvulsant and neuroprotective properties, induced growing interest on 2,3-benzodiazepine derivatives. This review covers the chemistry and pharmacology of this important class of AMPA receptor antagonists.

Cite this article as:

Zappala M., Grasso S., Micale N., Polimeni S. and De Micheli C., synthesis and Structure-Activity Relationships of 2,3-Benzodiazepines as AMPA Receptor Antagonists, Mini-Reviews in Medicinal Chemistry 2001; 1 (3) . https://dx.doi.org/10.2174/1389557013406783