Nerve Membrane Ion Channels as the Target Site of Insecticides

Title: Nerve Membrane Ion Channels as the Target Site of Insecticides

Volume: 2 Issue: 4

Author(s): Toshio Narahashi

Affiliation:

Keywords: imidacloprid, insecticide, Ion channel, neurotoxicant, indoxacarb

Abstract: Most insecticides are potent neurotoxicants that act on various neuroreceptors and ion channels. However, the major target receptors are limited to sodium channels, GABA receptors, and nicotinic acetylcholine receptors. DDT and pyrethroids act similarly on sodium channels to keep them open leading to hyperexcitation. Indoxacarb inhibits sodium channels and certain subtypes of nicotinic receptors. Dieldrin, lindane and fipronil block GABA receptors. Imidacloprid modulates nicotinic receptors in a complex manner. Spinosads major target site appears to be nicotinic receptors.

Cite this article as:

Narahashi Toshio, Nerve Membrane Ion Channels as the Target Site of Insecticides, Mini-Reviews in Medicinal Chemistry 2002; 2 (4) . https://dx.doi.org/10.2174/1389557023405927