Non-genomic Effects of Steroid Hormones on Membrane Channels

J.   C.   Herve

doi:10.2174/1389557023405981

Abstract

Steroid hormones may possess two distinct actions, a delayed genomic influence and the rapid nongenomic effects, which may act in concert. Nongenomic effect may be mediated by putative membrane receptors or due to allosteric interactions of steroids with membrane proteins (e.g. ionic channels), inducing rapid changes in protein / receptor / channel activation or inhibition.

Keywords: steroid hormone, membrane channel, membrane protein

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Mini-Reviews in Medicinal Chemistry

Title: Non-genomic Effects of Steroid Hormones on Membrane Channels

Volume: 2 Issue: 4

Author(s): J. C. Herve

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Keywords: steroid hormone, membrane channel, membrane protein

Abstract: Steroid hormones may possess two distinct actions, a delayed genomic influence and the rapid nongenomic effects, which may act in concert. Nongenomic effect may be mediated by putative membrane receptors or due to allosteric interactions of steroids with membrane proteins (e.g. ionic channels), inducing rapid changes in protein / receptor / channel activation or inhibition.

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Herve C. J., Non-genomic Effects of Steroid Hormones on Membrane Channels, Mini-Reviews in Medicinal Chemistry 2002; 2 (4) . https://dx.doi.org/10.2174/1389557023405981