Heterotrimeric G Proteins Control Diverse Pathways of Transmembrane Signaling, a Base for Drug Discovery

Yves      Landry; J.   P.   Gies

doi:10.2174/1389557023405945

Abstract

Heptahelical receptors are coupled to heterotrimeric GTP-binding proteins (G proteins) which transduce most signals through their a and bg subunits to effectors including adenylylcyclases, ion channels, phospholipases Cb, and phosphoinositide 3-kinases. The diversity of G proteins, their effectors and regulators (RGS proteins), supports the interest of these protein families as potential drug targets.

Keywords: heterotrimeric g protein, transmambrane signaling, heptahelical receptor, r g s protein

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