Abstract
Recent studies have demonstrated that protein tyrosine phosphatase 1B (PTP1B) is involved in the down regulation of insulin signaling. Selective inhibitors of PTP1B hold much promise for the treatment of type 2 diabetes mellitus and obesity. Consequently much effort, by both industry and academia, has been devoted towards the development of PTP1B specific inhibitors. This article gives an overview of reports that have appeared in the primary scientific literature on the development of PTP1B inhibitors, starting from the days of early development up to September of 2002.
Keywords: Protein Tyrosine Phosphatase
Current Topics in Medicinal Chemistry
Title: Inhibitors of Protein Tyrosine Phosphatase 1B (PTP1B)
Volume: 3 Issue: 7
Author(s): Scott D. Taylor
Affiliation:
Keywords: Protein Tyrosine Phosphatase
Abstract: Recent studies have demonstrated that protein tyrosine phosphatase 1B (PTP1B) is involved in the down regulation of insulin signaling. Selective inhibitors of PTP1B hold much promise for the treatment of type 2 diabetes mellitus and obesity. Consequently much effort, by both industry and academia, has been devoted towards the development of PTP1B specific inhibitors. This article gives an overview of reports that have appeared in the primary scientific literature on the development of PTP1B inhibitors, starting from the days of early development up to September of 2002.
Export Options
About this article
Cite this article as:
Taylor D. Scott, Inhibitors of Protein Tyrosine Phosphatase 1B (PTP1B), Current Topics in Medicinal Chemistry 2003; 3 (7) . https://dx.doi.org/10.2174/1568026033452311
DOI https://dx.doi.org/10.2174/1568026033452311 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
Call for Papers in Thematic Issues
Medicinal Chemistry Advancement in Life-Threatening Diseases
The current issue will highlight concise reports that specify ground-breaking insights, including the novel discovery of drug targets and their action mechanism or drugs of novel classes. These are projected to encourage medicinal chemistry future efforts to address the most challenging medical needs. The current issue highlights further efforts to ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Glucagon and Glucagon-Like Peptide Receptors as Drug Targets
Current Pharmaceutical Design Strategies for Skeletal Muscle Targeting in Drug Discovery
Current Pharmaceutical Design Longevity Pathways (mTOR, SIRT, Insulin/IGF-1) as Key Modulatory Targets on Aging and Neurodegeneration
Current Topics in Medicinal Chemistry Pharmacological Effects of Saffron and its Constituents in Ocular Disorders from in vitro Studies to Clinical Trials: A Systematic Review
Current Neuropharmacology Influence of Passion Fruit (Passiflora edulis, f. flavicarpa, DEG) Juice Sweetened with Sucrose, Saccharin and Cyclamate on Blood Glucose in Normal and Diabetic Rats (Rattus norvegicus)
The Natural Products Journal The Hypothalamic-Neurohypophyseal System: Current and Future Treatment of Vasopressin and Oxytocyn Related Disorders
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery (Discontinued) Prevalence, Severity and Characteristics of Tardive Dyskinesia Among Schizophrenia Patients in an Israeli Psychiatric Center
Current Psychopharmacology African Plants with Antidiabetic Potentials: Beyond Glycaemic Control to Central Nervous System Benefits
Current Diabetes Reviews Knowledge and Awareness of Oral Manifestations of Diabetes Mellitus and Oral Health Assessment among Diabetes Mellitus Patients- A Cross Sectional Study
Current Diabetes Reviews Determination of Chemical Composition and α-amylase Inhibitory Effect of New Propolis Extracts
Combinatorial Chemistry & High Throughput Screening Multiple Defects in Energy Metabolism in Alzheimers Disease
Current Drug Targets Molecular Mechanisms of Liver Cancer
Anti-Cancer Agents in Medicinal Chemistry Autoimmune Diseases and Atherosclerosis: The Inflammatory Connection
Current Immunology Reviews (Discontinued) Endoplasmic Reticulum Stress in Arterial Smooth Muscle Cells: A Novel Regulator of Vascular Disease
Current Cardiology Reviews Oxidative Stress in Diabetic Nephropathy
Current Medicinal Chemistry Equol is Neuroprotective During Focal Cerebral Ischemia and Reperfusion that Involves p-Src and gp91<sup>phox</sup>
Current Neurovascular Research Transgenerational Inheritance in the Offspring of Pregnant Women with Metabolic Syndrome
Current Pharmaceutical Biotechnology Genetic Basis of Ureterocele
Current Genomics Contemporary Overview on Clinical Trials and Future Prospects of Hepato-protective Herbal Medicines
Reviews on Recent Clinical Trials Phenylbutyric Acid: Simple Structure - Multiple Effects
Current Pharmaceutical Design