Evaluation of Effect of Triterpenes and Limonoids on Cell Growth, Cell Cycle and Apoptosis in Human Tumor Cell Lines

Title: Evaluation of Effect of Triterpenes and Limonoids on Cell Growth, Cell Cycle and Apoptosis in Human Tumor Cell Lines

Volume: 10 Issue: 10

Author(s): Cristiane M. Cazal, Kantima Choosang, Vanessa Gisele P. Severino, Marcio S. Soares, Andre Lucio F. Sarria, Joao B. Fernandes, Maria Fatima G.F. Silva, Paulo Cezar Vieira, Pannee Pakkong, Gabriela M. Almeida, M. Helena Vasconcelos, Maria S.J. Nascimento and Madalena M.M. Pinto

Affiliation:

Keywords: Anticancer, apoptosis, breast adenocarcinoma, cell cycle arrest, limonoids, melanoma, non-small lung cancer, triterpenes, MCF-7, NCI-H460, NMR, Growth Assay, SRB, HDFC

Abstract: Six triterpenes and eight limonoids were evaluated for their capacity to inhibit the growth of three human tumour cell lines, breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and melanoma (A375-C5). The mechanisms involved in the observed cell growth arrest of the four most potent compounds were carried out by studying their effect in cell cycle profile and programmed cell death. The results showed that one triterpene (odoratol) and two limonoids (gedunin and cedrelone) caused cell cycle arrest while only the limonoids gedunin and cedrelone were found to be very potent inducers of apoptosis.

Cite this article as:

M. Cazal Cristiane, Choosang Kantima, Gisele P. Severino Vanessa, S. Soares Marcio, Lucio F. Sarria Andre, B. Fernandes Joao, Fatima G.F. Silva Maria, Cezar Vieira Paulo, Pakkong Pannee, M. Almeida Gabriela, Helena Vasconcelos M., S.J. Nascimento Maria and M.M. Pinto Madalena, Evaluation of Effect of Triterpenes and Limonoids on Cell Growth, Cell Cycle and Apoptosis in Human Tumor Cell Lines, Anti-Cancer Agents in Medicinal Chemistry 2010; 10 (10) . https://dx.doi.org/10.2174/187152010794728620