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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

A Simple Parameter Relating Sequences with Folding Rates of Small α Helical Proteins

Author(s): Hui Shao, Yi Peng and Zong-Hao Zeng

Volume 10, Issue 3, 2003

Page: [277 - 280] Pages: 4

DOI: 10.2174/0929866033478906

Price: $65

Abstract

It is found that the helix parameter (HP), which favors clustering of non-polar residues, is linearly correlated with the logarithms of rate constants of folding of small two-state α-helical proteins. The definition is HP = NH-1 Σ [fi+ (fi-1+fi+1) / 2], where fi=1 or -1, if the ith residue is hydrophobic or hydrophilic, respectively, NH is the number of hydrophobic residues and the summation is taken over the hydrophobic residues.

Keywords: helical proteins, helix parameter, non-polar residues, two-state helical proteins


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