Oxidation of Goat Hepatic Galectin-1 Induces Change in Secondary Structure

Title: Oxidation of Goat Hepatic Galectin-1 Induces Change in Secondary Structure

Volume: 10 Issue: 3

Author(s): Abhay H. Pande, Rajesh K. Gupta Sumati and Krishnan Hajela

Affiliation:

Keywords: galectin-1, oxidation, conformational change

Abstract: Galectin-1 requires a reducing environment for its lectin activity and the carbohydrate binding function is destroyed in oxidizing condition. In this report we provide direct evidence that the oxidation of goat hepatic galectin-1 perturbs its carbohydrate recognition domain and this could be due to changes in secondary structure of goat hepatic galectin-1. Conformational changes in goat hepatic galectin-1 due to oxidation were investigated by absorption, fluorescence and circular dichroism measurements.

Cite this article as:

Pande H. Abhay, Sumati K. Gupta Rajesh and Hajela Krishnan, Oxidation of Goat Hepatic Galectin-1 Induces Change in Secondary Structure, Protein & Peptide Letters 2003; 10 (3) . https://dx.doi.org/10.2174/0929866033478960

DOI https://dx.doi.org/10.2174/0929866033478960	Print ISSN 0929-8665
Publisher Name Bentham Science Publisher	Online ISSN 1875-5305