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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Molecular Diversity of Hydroxamic Acids: Part II. Potential Therapeutic Applications

Author(s): Boliang Lou and Kexin Yang

Volume 3, Issue 6, 2003

Page: [609 - 620] Pages: 12

DOI: 10.2174/1389557033487872

Price: $65

Abstract

A hydroxamic acid moiety has been demonstrated as the key structural element in many highly potent and selective inhibitors against a variety of metalloprotease enzymes, such as MMPs, TACE, HDAC, PDF, etc. Over the last several years, there has been a rapid growth of literature and patent applications dealing with the development of the hydroxamic acid-based inhibitors. This review highlights the most recent examples to show their potential therapeutic applications.

Keywords: hydroxamic acids, mmps, tace, hdac, hydroxamic acid-based inhibitors


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