Isoquinoline Alkaloids from Duguetia Vallicola Stem Bark with Antiplasmodial Activity

E.      Perez; J.      Saez; S.      Blair; X.      Franck; B.      Figadere

doi:10.2174/1570178043488743

Abstract

Duguevalline (1), a novel aporphinoid alkaloid, in addition to four known alkaloids, cleistopholine (2), O-methylmoschatoline (3), (-)-oliveroline (4) and (-)-oliveridine (5), were isolated and characterized from Duguetia vallicola stems. Structural elucidation of these compounds was established by spectroscopic methods. Among them, alkaloids (2) and (4) exhibited antiplasmodial activity against Plasmodium falciparum.

Keywords: isoquinoline alkaloids, duguetia vallicola, annonaceae, antiplasmodial

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Letters in Organic Chemistry

Title: Isoquinoline Alkaloids from Duguetia Vallicola Stem Bark with Antiplasmodial Activity

Volume: 1 Issue: 1

Author(s): E. Perez, J. Saez, S. Blair, X. Franck and B. Figadere

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Keywords: isoquinoline alkaloids, duguetia vallicola, annonaceae, antiplasmodial

Abstract: Duguevalline (1), a novel aporphinoid alkaloid, in addition to four known alkaloids, cleistopholine (2), O-methylmoschatoline (3), (-)-oliveroline (4) and (-)-oliveridine (5), were isolated and characterized from Duguetia vallicola stems. Structural elucidation of these compounds was established by spectroscopic methods. Among them, alkaloids (2) and (4) exhibited antiplasmodial activity against Plasmodium falciparum.

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Perez E., Saez J., Blair S., Franck X. and Figadere B., Isoquinoline Alkaloids from Duguetia Vallicola Stem Bark with Antiplasmodial Activity, Letters in Organic Chemistry 2004; 1 (1) . https://dx.doi.org/10.2174/1570178043488743