Abstract
A new approach to two protected forms of (2S, 3S, 4S)-3-hydroxy-4-methylproline, a constituent of echinocandins and related oligopeptide antibiotics is reported. The method features a highly regioselective and diastereoselective reductive furylation of protected (2S, 3S)-3-methylmalimide and a chemoselective oxidative transformation of furyl to carboxyl as the key steps.
Keywords: proline, regioselectivity, addition, asymmetric synthesis, malic acid, echinocandins, furan, organometallics
Letters in Organic Chemistry
Title: A New Approach to (2S, 3S, 4S)-3-Hydroxy-4-Methylproline, A Subunit in Echinocandin B and Related Oligopeptide Antibiotics
Volume: 1 Issue: 1
Author(s): P.- Q. Huang and W.- H. Meng
Affiliation:
Keywords: proline, regioselectivity, addition, asymmetric synthesis, malic acid, echinocandins, furan, organometallics
Abstract: A new approach to two protected forms of (2S, 3S, 4S)-3-hydroxy-4-methylproline, a constituent of echinocandins and related oligopeptide antibiotics is reported. The method features a highly regioselective and diastereoselective reductive furylation of protected (2S, 3S)-3-methylmalimide and a chemoselective oxidative transformation of furyl to carboxyl as the key steps.
Export Options
About this article
Cite this article as:
Huang Q. P.- and Meng H. W.-, A New Approach to (2S, 3S, 4S)-3-Hydroxy-4-Methylproline, A Subunit in Echinocandin B and Related Oligopeptide Antibiotics, Letters in Organic Chemistry 2004; 1 (1) . https://dx.doi.org/10.2174/1570178043488626
DOI https://dx.doi.org/10.2174/1570178043488626 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |

- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers