The Application of Quantitative Analytical Constructs for Chemistry Optimization, Monomer Rehearsal and Reactivity Prediction in Solid Phase Library Synthesis

Title: The Application of Quantitative Analytical Constructs for Chemistry Optimization, Monomer Rehearsal and Reactivity Prediction in Solid Phase Library Synthesis

Volume: 1 Issue: 1

Author(s): Nigel J. Parr, Stephen C. McKeown, Mika K. Lindvall, Olivier E. Lorthioir, Miles S. Congreve and Stephen P. Watson

Affiliation:

Keywords: analytical methods, combinatorial chemistry, mass spectrometry, solid-phase synthesis

Abstract: The use of quantitative dual linker analytical constructs for the high-throughput generation of solid phase reaction data is described. This methodology can be applied to chemistry optimization, monomer rehearsal and monomer reactivity prediction as a tool to aid the production of solid phase compound libraries.

Cite this article as:

Parr J. Nigel, McKeown C. Stephen, Lindvall K. Mika, Lorthioir E. Olivier, Congreve S. Miles and Watson P. Stephen, The Application of Quantitative Analytical Constructs for Chemistry Optimization, Monomer Rehearsal and Reactivity Prediction in Solid Phase Library Synthesis, Letters in Organic Chemistry 2004; 1 (1) . https://dx.doi.org/10.2174/1570178043488653