An Efficient Synthesis of Hexahydro Oxaisoindolo[2,1-a]Quinoline Derivatives via the Diels-Alder Reactions

Title: An Efficient Synthesis of Hexahydro Oxaisoindolo[2,1-a]Quinoline Derivatives via the Diels-Alder Reactions

Volume: 1 Issue: 1

Author(s): Vladimir V. Kouznetsov, Fedor I. Zubkov, Uriel Mora Cruz, Leonid G. Voskressensky, Leonor Y. Vargas Mendez, Luis Astudillo and Elena E. Stashenko

Affiliation:

Keywords: Hexahydro Oxaisoindolo[2,1-a]Quinoline, diastereoselectivity, 2,4-disustituted, tetrahydroquinolines

Abstract: The straightforward synthesis of new carboxylic acids with hexahydro-oxaisoindolo[2,1- a]quinoline core from the 2,4-disustituted 1,2,3,4-tetrahydroquinolines bearing a furan fragment via the intramolecular Diels-Alder reaction has been proposed. It was demonstrated that synthesis of key precursors can be realized with excellent level of diastereoselectivity either by imino-Diels-Alder reaction or multicomponent condensation approach.

Cite this article as:

Kouznetsov V. Vladimir, Zubkov I. Fedor, Cruz Mora Uriel, Voskressensky G. Leonid, Mendez Y. Vargas Leonor, Astudillo Luis and Stashenko E. Elena, An Efficient Synthesis of Hexahydro Oxaisoindolo[2,1-a]Quinoline Derivatives via the Diels-Alder Reactions, Letters in Organic Chemistry 2004; 1 (1) . https://dx.doi.org/10.2174/1570178043488572