Recombinant Murine Polyoma Virus-like-particles Induce Protective Antitumour Immunity

Title: Recombinant Murine Polyoma Virus-like-particles Induce Protective Antitumour Immunity

Volume: 1 Issue: 2

Author(s): M. Brinkman, J. Walter, I. Jennes, M. Neugebauer, W. Bertling, S. Grein, M. Thies, M. Weigand, T. Beyer and M. Herrmann

Affiliation:

Keywords: peptide delivery, cell-mediated immunity, virus-like-particles, tumour vaccination

Abstract: Subcutaneous vaccination of mice with chimerical polyomavirus-likeparticles consisting of a VP1-ovalbumin (OVA252-270) fusion protein induced immunodominant H-2Kb-restricted and OVA257-264-specific CD8 T cells in mice. Single immunisations with VP1-OVA252-270 capsoids failed to have beneficial effects on tumour protection, only double vaccinations in weekly intervals protected mice from lethal MO5 melanoma challenge.

Cite this article as:

Brinkman M., Walter J., Jennes I., Neugebauer M., Bertling W., Grein S., Thies M., Weigand M., Beyer T. and Herrmann M., Recombinant Murine Polyoma Virus-like-particles Induce Protective Antitumour Immunity, Letters in Drug Design & Discovery 2004; 1 (2) . https://dx.doi.org/10.2174/1570180043485545