Pharmacokinetic Study and Trial for Preparation of Enteric-Coated Capsule Containing Insulinomimetic Vanadyl Compounds: Implications for Clinical Use

Title: Pharmacokinetic Study and Trial for Preparation of Enteric-Coated Capsule Containing Insulinomimetic Vanadyl Compounds: Implications for Clinical Use

Volume: 4 Issue: 1

Author(s): H. Sakurai, J. Fugono and H. Yasui

Affiliation:

Keywords: Vanadyl compound, insulinomimetic activity, diabetes mellitus, blood circulation monitoring-electron, paramagnetic resonance (BCM-EPR), pharmacokinetic analysis, bioavailability, enteric-coated capsule

Abstract: To treat patients suffering from diabetes mellitus, we developed several types of orally active vanadyl complexes to replace painful insulin injections, and prepared them in the form of enteric-coated capsules containing vanadium compounds. Pharmacokinetic analysis demonstrated that these capsules enhance the bioavailability of pharmacologically active vanadyl species.

Cite this article as:

H. Sakurai , J. Fugono and H. Yasui , Pharmacokinetic Study and Trial for Preparation of Enteric-Coated Capsule Containing Insulinomimetic Vanadyl Compounds: Implications for Clinical Use, Mini-Reviews in Medicinal Chemistry 2004; 4 (1) . https://dx.doi.org/10.2174/1389557043487574