“Lock-in”-cycloSal-Pronucleotides - A New Generation of Chemical Trojan Horses?

Chris      Meier; Manuel   F.H.   Ruppel; Dalibor      Vukadinovic; Jan      Balzarini

doi:10.2174/1389557043403972

Abstract

The cycloSal-concept is one example of a successful nucleotide delivering system (pronucleotide). For several nucleoside analogues, the cycloSal-approach improved the antiviral potency and the applicability of the nucleosides could be broadened. Here, a conceptional extension of the original design of the cycloSalsystem will be discussed.

Keywords: cyclosal-pronucleotides, trojan horses, pronucleotide, cyclosaligenyl-nucleotides

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Mini-Reviews in Medicinal Chemistry

Title: “Lock-in”-cycloSal-Pronucleotides - A New Generation of Chemical Trojan Horses?

Volume: 4 Issue: 4

Author(s): Chris Meier, Manuel F.H. Ruppel, Dalibor Vukadinovic and Jan Balzarini

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Keywords: cyclosal-pronucleotides, trojan horses, pronucleotide, cyclosaligenyl-nucleotides

Abstract: The cycloSal-concept is one example of a successful nucleotide delivering system (pronucleotide). For several nucleoside analogues, the cycloSal-approach improved the antiviral potency and the applicability of the nucleosides could be broadened. Here, a conceptional extension of the original design of the cycloSalsystem will be discussed.

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Meier Chris, Ruppel F.H. Manuel, Vukadinovic Dalibor and Balzarini Jan, “Lock-in”-cycloSal-Pronucleotides - A New Generation of Chemical Trojan Horses?, Mini-Reviews in Medicinal Chemistry 2004; 4 (4) . https://dx.doi.org/10.2174/1389557043403972