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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Aryloxy Phosphoramidate Triesters as Pro-Tides

Author(s): Dominique Cahard, Christopher McGuigan and Jan Balzarini

Volume 4, Issue 4, 2004

Page: [371 - 381] Pages: 11

DOI: 10.2174/1389557043403936

Price: $65

Abstract

We herein describe the development of aryloxy phosphoramidate triesters as an effective pro-tide motif for the intracellular delivery of charged bio-active antiviral nucleoside monophosphates. The review covers the discovery of such aryl phosphoramidates, their mechanism of action and structure-activity relationships. The application of this strategy to a range of antiviral nucleosides is highlighted.

Keywords: nucleotide, pro-drug, phosphoramidate


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