Leptin, Estrogens and Cancer

Title: Leptin, Estrogens and Cancer

Volume: 6 Issue: 8

Author(s): Maria del Carmen Maeso Fortuny, Buenaventura Brito Diaz and Antonio Cabrera de Leon

Affiliation:

Keywords: Cancer, leptin, estrogen receptors

Abstract: Obesity is a state of leptin resistance in which the membrane leptin receptor and the JAK-STAT pathway are blocked. This leads to increased intracellular concentrations of lipid metabolites, increased non-oxidative metabolism by adipocytes, and stimulation of the cell estrogen cycle. These factors are potentially oncogenic via the shared mitogen-activated protein kinase (MAPK), mitogen/extracellular signal-regulated kinase (MEK) and extracellular signal-regulated kinase (ERK) cellular pathways.

Cite this article as:

Maeso Fortuny Maria del Carmen, Brito Diaz Buenaventura and Cabrera de Leon Antonio, Leptin, Estrogens and Cancer, Mini-Reviews in Medicinal Chemistry 2006; 6 (8) . https://dx.doi.org/10.2174/138955706777934973