Synthetic Strategies Towards O6-Substituted Guanine Derivatives and their Application in Medicine

Title: Synthetic Strategies Towards O6-Substituted Guanine Derivatives and their Application in Medicine

Volume: 2 Issue: 2

Author(s): R. Schirrmacher, E. Schirrmacher, U. Mühlhausen, B. Kaina and B. Wängler

Affiliation:

Keywords: substituted guanines, agt inhibitors, catalysis, rearrangement

Abstract: This article focuses on the synthesis of O6-substituted guanine derivatives and their application in medicine. O6-substituted guanines with alky-, aryl and heteroaryl-substituents and sterically challenging substituents have been described. The synthetic strategies are mainly based on different leaving groups in the 6-position of the guanine. Here, synthesis of various derivatives are described as well as the different synthetic pathways to obtain the synthetic precursors, which are prerequisites for efficient syntheses.

Cite this article as:

Schirrmacher R., Schirrmacher E., Mühlhausen U., Kaina B. and Wängler B., Synthetic Strategies Towards O6-Substituted Guanine Derivatives and their Application in Medicine, Current Organic Synthesis 2005; 2 (2) . https://dx.doi.org/10.2174/1570179053545369