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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

A Very Efficient Synthesis of (1H)-1,5-Diazaanthracene-2,9,10-triones

Author(s): J. Ignacio Ubeda, Mercedes Villacampa and Carmen Avendano

Volume 2, Issue 4, 2005

Page: [374 - 377] Pages: 4

DOI: 10.2174/1570178054038867

Price: $65

Abstract

Acylation of ortho-lithiated species derived from N,O-dipivaloyl-6-amino-5,8-dimethoxy-4-methyl- 2(1H)-quinolinone, followed by condensation with carbonyl reagents and in situ N-deprotection gave 7-alkyl or 6,7-dialkyl-9,10-dimethoxy-4-methyl-1,5-diaza-2(1H)-anthracenones, which were finally oxidised to the title compounds.

Keywords: acylation, ortho-assisted lithiation, diazaanthraquinones, friedlander reaction, oxidative demethylation


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