A Very Short and Efficient Synthesis of Preclamol

Title: A Very Short and Efficient Synthesis of Preclamol

Volume: 2 Issue: 2

Author(s): Arnault de Filippis, Domingo Gomez Pardo and Janine Cossy

Affiliation:

Keywords: preclamol, arylations, lactams, palladium, zinc, coupling reaction

Abstract: A very short and efficient synthesis of preclamol is described. The key step is the palladiumcatalysed arylation of the zinc enolate of N-propyl-2-piperidinone.

Cite this article as:

Filippis de Arnault, Pardo Gomez Domingo and Cossy Janine, A Very Short and Efficient Synthesis of Preclamol, Letters in Organic Chemistry 2005; 2 (2) . https://dx.doi.org/10.2174/1570178053202883