Unusual Solute Protection Against Pressure Inactivation of Yeast Alcohol Dehydrogenase

Title: Unusual Solute Protection Against Pressure Inactivation of Yeast Alcohol Dehydrogenase

Volume: 12 Issue: 8

Author(s): Gene Kidman and Dexter B. Northrop

Affiliation:

Keywords: yeast alcohol dehydrogenase, hydrostatic pressure, protein stabilization, barostabilization, osmolytes, osmoprotectorants

Abstract: A 3:1 combination of sucrose and glycine provides significantly greater protection against pressure-induced inactivation of yeast alcohol dehydrogenase than either solute alone. Trehalose, alone, gives much greater protection than sucrose alone, but not so in combination with glycine. These are striking new findings that cannot be accounted for by current theories of protein stabilization.

Cite this article as:

Kidman Gene and Northrop B. Dexter, Unusual Solute Protection Against Pressure Inactivation of Yeast Alcohol Dehydrogenase, Protein & Peptide Letters 2005; 12 (8) . https://dx.doi.org/10.2174/0929866054864265

DOI https://dx.doi.org/10.2174/0929866054864265	Print ISSN 0929-8665
Publisher Name Bentham Science Publisher	Online ISSN 1875-5305