Phenyldihydroxypyrimidines as HCV NS5B RNA Dependent RNA Polymerase Inhibitors. Part II: Sulfonamides

Title: Phenyldihydroxypyrimidines as HCV NS5B RNA Dependent RNA Polymerase Inhibitors. Part II: Sulfonamides

Volume: 2 Issue: 6

Author(s): S. Ponzi, C. Giuliano, M. Donghi, M. Poma, V. G. Matassa and I. Stansfield

Affiliation:

Keywords: hcv, ns5b polymerase, inhibitors, phenyldihydroxypyrimidines, sulfonamides

Abstract: 5,6-Dihydroxypyrimidine-4-carboxylic acids are a promising series of hepatitis C virus (HCV) NS5B polymerase inhibitors that bind at the active site of the enzyme. Here we report the evolution and SAR of a series of 2-{2-[(arylsulfonyl)amino]phenyl analogues that show greater than 2 orders of magnitude improved activity over the original lead.

Cite this article as:

Ponzi S., Giuliano C., Donghi M., Poma M., Matassa G. V. and Stansfield I., Phenyldihydroxypyrimidines as HCV NS5B RNA Dependent RNA Polymerase Inhibitors. Part II: Sulfonamides, Letters in Drug Design & Discovery 2005; 2 (6) . https://dx.doi.org/10.2174/1570180054771527