Phenyldihydroxypyrimidines as HCV NS5B RNA Dependent RNA Polymerase Inhibitors. Part I: Amides and Ureas

Title: Phenyldihydroxypyrimidines as HCV NS5B RNA Dependent RNA Polymerase Inhibitors. Part I: Amides and Ureas

Volume: 2 Issue: 6

Author(s): B. Crescenzi, M. Poma, J. M. Ontoria, A. Marchetti, E. Nizi, V. G. Matassa and C. Gardelli

Affiliation:

Keywords: hcv ns5b rna polymerase, dihydroxypyrimidines, sar, inhibitors, amides, ureas

Abstract: 2-Phenyl-5,6-dihydroxypyrimidine-4-carboxylic acids were discovered as specific inhibitors of the NS5B polymerase of the Hepatitis C Virus. In-depth structure-activity investigations at the ortho and meta positions of the phenyl ring were undertaken, and compounds with greatly improved activity over the original lead have been discovered.

Cite this article as:

Crescenzi B., Poma M., Ontoria M. J., Marchetti A., Nizi E., Matassa G. V. and Gardelli C., Phenyldihydroxypyrimidines as HCV NS5B RNA Dependent RNA Polymerase Inhibitors. Part I: Amides and Ureas, Letters in Drug Design & Discovery 2005; 2 (6) . https://dx.doi.org/10.2174/1570180054771491

DOI https://dx.doi.org/10.2174/1570180054771491	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X