Abstract
2-Phenyl-5,6-dihydroxypyrimidine-4-carboxylic acids were discovered as specific inhibitors of the NS5B polymerase of the Hepatitis C Virus. In-depth structure-activity investigations at the ortho and meta positions of the phenyl ring were undertaken, and compounds with greatly improved activity over the original lead have been discovered.
Keywords: hcv ns5b rna polymerase, dihydroxypyrimidines, sar, inhibitors, amides, ureas
Letters in Drug Design & Discovery
Title: Phenyldihydroxypyrimidines as HCV NS5B RNA Dependent RNA Polymerase Inhibitors. Part I: Amides and Ureas
Volume: 2 Issue: 6
Author(s): B. Crescenzi, M. Poma, J. M. Ontoria, A. Marchetti, E. Nizi, V. G. Matassa and C. Gardelli
Affiliation:
Keywords: hcv ns5b rna polymerase, dihydroxypyrimidines, sar, inhibitors, amides, ureas
Abstract: 2-Phenyl-5,6-dihydroxypyrimidine-4-carboxylic acids were discovered as specific inhibitors of the NS5B polymerase of the Hepatitis C Virus. In-depth structure-activity investigations at the ortho and meta positions of the phenyl ring were undertaken, and compounds with greatly improved activity over the original lead have been discovered.
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Cite this article as:
Crescenzi B., Poma M., Ontoria M. J., Marchetti A., Nizi E., Matassa G. V. and Gardelli C., Phenyldihydroxypyrimidines as HCV NS5B RNA Dependent RNA Polymerase Inhibitors. Part I: Amides and Ureas, Letters in Drug Design & Discovery 2005; 2 (6) . https://dx.doi.org/10.2174/1570180054771491
DOI https://dx.doi.org/10.2174/1570180054771491 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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