The Derivation of a Potential Transition-State for the Reduction Reaction Catalysed by 17β -Hydroxysteroid Dehydrogenase Type 3 (17β -HSD) - An Approximate Representation of its Active Site for Use in Drug Design and Discovery

Title: The Derivation of a Potential Transition-State for the Reduction Reaction Catalysed by 17β -Hydroxysteroid Dehydrogenase Type 3 (17β -HSD) - An Approximate Representation of its Active Site for Use in Drug Design and Discovery

Volume: 4 Issue: 7

Author(s): Moniola S. Olusanjo and Sabbir Ahmed

Affiliation:

Keywords: Type 3, Isozyme, 17β-Hydroxysteroid dehydrogenase, 17β-HSD3, Transition-state, Reduction reaction

Abstract: The approximate representation of the active site of the type 3 isozyme of the enzyme 17β-hydroxysteroid dehydrogenase (17β-HSD3) has been derived from the consideration of the proposed mechanism for the reduction reaction. Using the transition-state (TS), the mode of action of a number of inhibitors has been rationalised.

Cite this article as:

Olusanjo S. Moniola and Ahmed Sabbir, The Derivation of a Potential Transition-State for the Reduction Reaction Catalysed by 17β -Hydroxysteroid Dehydrogenase Type 3 (17β -HSD) - An Approximate Representation of its Active Site for Use in Drug Design and Discovery, Letters in Drug Design & Discovery 2007; 4 (7) . https://dx.doi.org/10.2174/157018007781788525