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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Artemisinin Delays Sphingolipid Biosynthesis in Plasmodium falciparum

Author(s): Francoise Debierre-Grockiego, Jorg Schmidt, Eliezer Flescher and Ralph T. Schwarz

Volume 4, Issue 7, 2007

Page: [524 - 526] Pages: 3

DOI: 10.2174/157018007781788499

Price: $65

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Abstract

Artemisinin induces the growth inhibition of Plasmodium falciparum by sphingomyelinase-generated ceramide. To understand whether artemisinin could have another effect, sphingolipid biosynthesis was studied. Our result shows that a delay in the formation of final products (globoside, cerebrosides) production might be involved in the increase of ceramide.

Keywords: Plasmodium, Artemisinin, Serine, Ceramide, Sphingomyelin


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