Pigment Epithelium-Derived Factor (PEDF) Prevents Advanced Glycation End Products (AGEs)-Elicited Endothelial Nitric Oxide Synthase (eNOS) Reduction Through Its Anti-Oxidative Properties

Title: Pigment Epithelium-Derived Factor (PEDF) Prevents Advanced Glycation End Products (AGEs)-Elicited Endothelial Nitric Oxide Synthase (eNOS) Reduction Through Its Anti-Oxidative Properties

Volume: 14 Issue: 8

Author(s): Sho-ichi Yamagishi, Seiji Ueda, Takanori Matsui, Kazuo Nakamura, Tsutomu Imaizumi, Masayoshi Takeuchi and Seiya Okuda

Affiliation:

Keywords: AGEs, eNOS, oxidative stress, PEDF, peroxynitrite

Abstract: PEDF is an effective inhibitor of angiogenesis in the eye with neuronal differentiating activity. Here, we show that PEDF prevents the AGEs-elicited eNOS reduction through its anti-oxidative properties. Our present study suggests that PEDF may also play a protective role against atherosclerosis.

Cite this article as:

Sho-ichi Yamagishi , Seiji Ueda , Takanori Matsui , Kazuo Nakamura , Tsutomu Imaizumi , Masayoshi Takeuchi and Seiya Okuda , Pigment Epithelium-Derived Factor (PEDF) Prevents Advanced Glycation End Products (AGEs)-Elicited Endothelial Nitric Oxide Synthase (eNOS) Reduction Through Its Anti-Oxidative Properties, Protein & Peptide Letters 2007; 14 (8) . https://dx.doi.org/10.2174/092986607781483705