FTY720: A Most Promising Immunosuppressant Modulating Immune Cell Functions

Title: FTY720: A Most Promising Immunosuppressant Modulating Immune Cell Functions

Volume: 7 Issue: 8

Author(s): Zhiren Zhang and Hermann J. Schluesener

Affiliation:

Keywords: FTY720, lymphocytes, monocytes, dendritic cells, endothelial cells, transplantation, autoimmune diseases, tumors

Abstract: FTY720, the pharmacological analog of S1P, acts as an agonist of sphingosine-1-phosphate receptors, resulting in the inhibition of lymphocyte egress from secondary lymphoid tissues and thymocytes from the thymus, peripheral lymphopenia and interfering with normal functions of several other cell types. FTY720 has been clinically tried for transplantation and multiple sclerosis, showing promising protective effects. This review will summarize potential applications and effects of FTY720.

Cite this article as:

Zhiren Zhang and Hermann J. Schluesener , FTY720: A Most Promising Immunosuppressant Modulating Immune Cell Functions, Mini-Reviews in Medicinal Chemistry 2007; 7 (8) . https://dx.doi.org/10.2174/138955707781387948