From Head to Tail: Microwave-Assisted Synthesis of Para Hydrazine Nicotinamide Phenylalanine8-Oxytocin Derivatives

Title: From Head to Tail: Microwave-Assisted Synthesis of Para Hydrazine Nicotinamide Phenylalanine8-Oxytocin Derivatives

Volume: 4 Issue: 4

Author(s): Alma D. Miranda-Olvera, Ignacio A. Rivero Espejel and Luis M. De Leon Rodriguez

Affiliation:

Keywords: Microwave, oxytocin, HYNIC, peptide, libraries, conjugate

Abstract: Currently, the generation of peptide ligand libraries where ligand position and identity are varied leading to the discovery of optimal peptide activity and stability is limited. Thus, in this work the synthesis of a p-Dde-Nα-Fmocphenylalanine residue is reported followed by its application in the microwave assisted synthesis of labeled HYNIC Phe8- oxitocine derivatives.

Cite this article as:

Alma D. Miranda-Olvera , Ignacio A. Rivero Espejel and Luis M. De Leon Rodriguez , From Head to Tail: Microwave-Assisted Synthesis of Para Hydrazine Nicotinamide Phenylalanine8-Oxytocin Derivatives, Letters in Organic Chemistry 2007; 4 (4) . https://dx.doi.org/10.2174/157017807781024246