A Mild and Efficient C-3 Allylic Alkylation of Indoles Catalyzed by FeCl3

Zhe Liu; Li Liu; Zahid Shafiq; Dong Wang; Yong-Jun Chen

doi:10.2174/157017807781024336

Abstract

A mild and efficient allylic alkylation of indole derivatives has been developed with high regioselectivity and excellent yields. In the presence of 1mol% FeCl3 catalyst, various indole derivatives could react with allylic acetates at room temperature to provide C-3 allylation products. A green synthesis of C-3 allylated indoles was developed employing FeCl3 as catalyst in water.

Keywords: Allylation, FeCl3, indole, Friedel-Crafts alkylation, allylic acetate

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Letters in Organic Chemistry

Title: A Mild and Efficient C-3 Allylic Alkylation of Indoles Catalyzed by FeCl3

Volume: 4 Issue: 4

Author(s): Zhe Liu, Li Liu, Zahid Shafiq, Dong Wang and Yong-Jun Chen

Affiliation:

Keywords: Allylation, FeCl3, indole, Friedel-Crafts alkylation, allylic acetate

Abstract: A mild and efficient allylic alkylation of indole derivatives has been developed with high regioselectivity and excellent yields. In the presence of 1mol% FeCl3 catalyst, various indole derivatives could react with allylic acetates at room temperature to provide C-3 allylation products. A green synthesis of C-3 allylated indoles was developed employing FeCl3 as catalyst in water.

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Zhe Liu , Li Liu , Zahid Shafiq , Dong Wang and Yong-Jun Chen , A Mild and Efficient C-3 Allylic Alkylation of Indoles Catalyzed by FeCl3, Letters in Organic Chemistry 2007; 4 (4) . https://dx.doi.org/10.2174/157017807781024336