Abstract
We demonstrate that olfactory bulbectomy produced oxidative and cell damage together with behavioural changes. This situation was reversed by fluoxetine administration. The data suggest that oxidative stress may represent common pathophysiological mechanisms in this experimental model, as well as that beneficial effect of fluoxetine may be mediated by antioxidative action.
Keywords: Lipid Peroxidation, caspase-3, GSH-peroxidase, selective serotonin reuptake inhibitors, Open Field Test
Letters in Drug Design & Discovery
Title: Effect of Fluoxetine on Brain Oxidative Stress, Neuronal Damage and Behavioural Induced in the Olfactory Bulbectomy Model of Depression
Volume: 4 Issue: 4
Author(s): Isaac Tunez, Francisco J. Medina, Ignacio Jimena and María del C. Munoz
Affiliation:
Keywords: Lipid Peroxidation, caspase-3, GSH-peroxidase, selective serotonin reuptake inhibitors, Open Field Test
Abstract: We demonstrate that olfactory bulbectomy produced oxidative and cell damage together with behavioural changes. This situation was reversed by fluoxetine administration. The data suggest that oxidative stress may represent common pathophysiological mechanisms in this experimental model, as well as that beneficial effect of fluoxetine may be mediated by antioxidative action.
Export Options
About this article
Cite this article as:
Tunez Isaac, Medina J. Francisco, Jimena Ignacio and Munoz C. María del, Effect of Fluoxetine on Brain Oxidative Stress, Neuronal Damage and Behavioural Induced in the Olfactory Bulbectomy Model of Depression, Letters in Drug Design & Discovery 2007; 4 (4) . https://dx.doi.org/10.2174/157018007784620013
DOI https://dx.doi.org/10.2174/157018007784620013 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
Related Journals
Related Books
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Involvement of Gaucher Disease Mutations in Parkinson Disease
Current Protein & Peptide Science Novel 1,3,4-Oxadiazole Fused Thiadiazole Derivatives: Synthesis and study of Anticancer Activities
Letters in Drug Design & Discovery Vascular Lesion Thickness in the Lenticulostriate Artery Region Serves as a Biomarker for Early Neurological Deterioration
Current Neurovascular Research Genetic Signatures of Centenarians: Implications for Achieving Successful Aging
Current Pharmaceutical Design Baseline Levels of Interleukine-6, Tumor-Necrosis Factor-Alpha and C-Reactive Protein in Treatment Naive Human Immunodeficiency Virus Infected Patients-A Study from a Tertiary-Care Hospital in Eastern India
Current Biomarkers (Discontinued) Maintenance of Gastrointestinal Glucose Homeostasis by the Gut-Brain Axis
Current Protein & Peptide Science Small Molecule Antagonists of Integrin Receptors
Current Medicinal Chemistry Medicinal Chemical and Pharmacological Aspects of Imidazole-Containing Histamine H3 Receptor Antagonists
Mini-Reviews in Medicinal Chemistry Update on the Use of Biologics in Lupus
Current Pharmaceutical Biotechnology Meet the Editorial Board
CNS & Neurological Disorders - Drug Targets Sports Participation and Alcohol Use Among Adolescents: The Impact of Measurement and Other Research Design Elements
Current Drug Abuse Reviews An Apple Plus a Brazil Nut a Day Keeps the Doctors Away: Antioxidant Capacity of Foods and their Health Benefits
Current Pharmaceutical Design Positive Social Interactions in a Lifespan Perspective with a Focus on Opioidergic and Oxytocinergic Systems: Implications for Neuroprotection
Current Neuropharmacology Recent Advances in the Design and Synthesis of Prednisolone and Methylprednisolone Conjugates
Current Pharmaceutical Design The Involvement of the Vasopressin System in Stress-Related Disorders
CNS & Neurological Disorders - Drug Targets Meet Our Editorial Board Member
CNS & Neurological Disorders - Drug Targets Synthesis of Coumarin Derivatives as Versatile Scaffolds for GSK-3β Enzyme Inhibition
Current Topics in Medicinal Chemistry Interactions between Antidepressants and Warfarin: A Review
Current Psychiatry Research and Reviews Frontiers for the Early Diagnosis of AD by Means of MRI Brain Imaging and Support Vector Machines
Current Alzheimer Research Commentary (Research Highlights: Transcranial Drug Delivery for Neurological Disorders)
CNS & Neurological Disorders - Drug Targets