Synthesis and Evaluation of 2-Substituted Fendiline Analogues as Antileukemics

Title: Synthesis and Evaluation of 2-Substituted Fendiline Analogues as Antileukemics

Volume: 4 Issue: 4

Author(s): James A. Wilkinson, Steven B. Rossington, Nicholas A. Coe, Nicholas Hirst, Alan T. McGown, John Leonard and Nigel Hussain

Affiliation:

Keywords: Fendiline, Antileukemic compounds, Diphenylmethanes

Abstract: A series of novel, 2-substituted derivatives of fendiline have been synthesised and their ability to inhibit growth of human leukaemia cells (K562) determined. Of these derivatives, the 2-hydroxy compounds 26 and 27 had a significantly greater inhibitory effect on K562 cells than fendiline.

Cite this article as:

Wilkinson A. James, Rossington B. Steven, Coe A. Nicholas, Hirst Nicholas, McGown T. Alan, Leonard John and Hussain Nigel, Synthesis and Evaluation of 2-Substituted Fendiline Analogues as Antileukemics, Letters in Drug Design & Discovery 2007; 4 (4) . https://dx.doi.org/10.2174/157018007784620068